For the cheapest flights to Madrid book 21 days before departure.
The most popular airlines on the route Brussels - Madrid: Ryanair (FR), Air Europa (UX), Iberia (IB).
The cheapest flights are on the route Brussels Intl Airport (BRU) - Barajas (MAD).
Direct flights last about 2h 15min.
Direct flights are available 7 days a week.
Direct flights: Ryanair (FR), Air Europa (UX), Brussels Airlines (SN).