For the cheapest flights to Prague book 17 days before departure.
The most popular airlines on the route Madrid - Prague: Smart Wings (QS), Czech Airlines (OK), Brussels Airlines (SN).
The cheapest flights are on the route Barajas (MAD) - Ruzyne (PRG).
Direct flights last about 2h 45min.
Direct flights are available 7 days a week.
Direct flights: Smart Wings (QS), Czech Airlines (OK), Iberia (IB).