For the cheapest flights to Brussels book 12 days before departure.
The most popular airlines on the route Pisa - Brussels: Ryanair (FR), Alitalia (AZ).
The cheapest flights are on the route Galileo Galilei (PSA) - Charleroi (CRL).
Direct flights last about 1h 50min.
Direct flights available 6 days a week - Tuesday, Wednesday, Thursday, Friday, Saturday, Sunday.
Direct flights: Ryanair (FR).