For the cheapest flights to Madrid book 11 days before departure.
The most popular airlines on the route Rome - Madrid: Ryanair (FR), Iberia (IB), Alitalia (AZ).
The cheapest flights are on the route Ciampino (CIA) - Barajas (MAD).
Direct flights last about 2h 35min.
Direct flights are available 7 days a week.
Direct flights: Ryanair (FR), Iberia (IB), Alitalia (AZ).