For the cheapest flights to Prague book 23 days before departure.
The most popular airlines on the route Rome - Prague: Ryanair (FR), Wizz Air (W6), Czech Airlines (OK).
The cheapest flights are on the route Ciampino (CIA) - Ruzyne (PRG).
Direct flights last about 1h 48min.
Direct flights are available 7 days a week.
Direct flights: Ryanair (FR), Czech Airlines (OK), Vueling (VY).